Endocrine Abstracts

Tumor angiogenesis is believed to result from an imbalance of pro- and anti-angiogenic factors. Angiogenesis is an important component in the development of thyroid goitre. Vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF) represents a family of specific endothelial cell mitogens involved in normal angiogenesis and in tumor development. Consequently, a panel of anti-angiogenic factors was addressed in a representative sample of VEGF receptor-2 (VEGFR-...

A higher incidence of nodular goitre and less differentiated types of thyroid carcinoma have been observed in iodine deficient regions. North-Eastern Poland was an area with a moderate deficiency of iodine until the introduction of the mandatory salt iodination in 1997 (30±10 mg KJ/kg NaCl). The aim of our study was to compare the incidence of goitre, thyroid carcinoma and urine excretion of iodine in the inhabitants of the North-Eastern Region of Poland in 1997 and 2005....